Anavar was first released in the U.S. in 1964 and had gained popularity until 1986, when it was severely reduced in production. The drug is now available under the name of Oxandrolone.

Because it was first developed for women and children with osteoporosis and impaired development, it is known to be a safe medication. The drug was also used to treat HIV, the Turner syndrome, anemia and burns. Anavar then became part of the field of sports medicine after a thorough investigation of its beneficial effects on humans. The drug produces NO masculinization and its side effects are quite rare, so it has gained popularity among athletes, particularly those involved in powerlifting and bodybuilding.